ALK GENE FUSIONS AND ROS1 GENE FUSIONS DETECTION KIT

ALK Gene Fusions and ROS1 Gene Fusions Detection Kit ALK gene fusions and ROS1 gene fusions define unique molecular subsets of non-small-cell lung cancer (NSCLC). EML4, KIF5B, TFG, KLC1 etc., are

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ALK Gene Fusions and ROS1 Gene Fusions Detection Kit

ALK gene fusions and ROS1 gene fusions define unique molecular subsets of non-small-cell lung cancer (NSCLC). EML4, KIF5B, TFG, KLC1 etc., are identified as fusion partners of ALK; SLC34A2, CD74, SDC4, EZR etc., are identified as fusion partners of ROSE These fusions lead to constitutive kinase activity and activation of downstream pathways, leading to carcinogenesis. It has been reported that the presence of the ALK gene fusions and ROS1 gene fusions are correlated with the efficacy of TKI therapy. Based on analysis of tumor messenger RNA, ALK gene fusions and ROS1 gene fusions can be detected by real-time PCR method.

Features

1. Selectable

Convenient pre-loaded format.

 

2. Universal

Convenient pre-loaded format.

 

3. Precise

Top sensitivity of 125 copies/rxn (ALK/ROS1).

 

4. Easy

Top sensitivity of 125 copies/rxn (ALK/ROS1).

 

5. Reliable

Internal and external controls included.

Intended Use

ALK Gene Fusions and ROS1 Gene Fusions Detection Kit is a real-time PCR assay for qualitative detection of 14 ALK gene fusions and 14 ROS1 gene fusions in human total RNA extracted from NSCLC formalin-fixed paraffin-embedded (FFPE) tumor tissue.

The kit is for in vitro diagnostic use and intended to be used by trained professionals in a laboratory environment.