ALK Gene Fusions and ROS1 Gene Fusions Detection Kit

ALK gene fusions and ROS1 gene fusions define unique molecular subsets of non-small-cell lung cancer (NSCLC). EML4, KIF5B, TFG, KLC1 etc., are identified as fusion partners of ALK; SLC34A2, CD74, SDC4, EZR etc., are identified as fusion partners of ROSE These fusions lead to constitutive kinase activity and activation of downstream pathways, leading to carcinogenesis. It has been reported that the presence of the ALK gene fusions and ROS1 gene fusions are correlated with the efficacy of TKI therapy. Based on analysis of tumor messenger RNA, ALK gene fusions and ROS1 gene fusions can be detected by real-time PCR method.