BRCA1 and BRCA2 gene are tumor suppressor genes involved in DNA damage repair. Mutations in BRCA1 and BRCA2 genes have been linked to the development of hereditary breast cancer and ovarian cancer. BRCA gene mutation detection has also been highly recommended by many oncology clinical guidelines such as NCCN, CSCO and ASBrS guidelines, and the mutation testing results can guide use of PARP inhibitors such as Olaparib, surgical planning and screening for individual with high risk of ovarian cancer and/or breast cancer.
BRCA1 AND BRCA2 GENE MUTATION DETECTION KIT
BRCA1 and BRCA2 gene are tumor suppressor genes involved in DNA damage repair. Mutations in BRCA1 and BRCA2 genes have been linked to the development of hereditary breast cancer and ovarian cancer. BR
Intended Use
BRCA1 and BRCA2 gene are tumor suppressor genes involved in DNA damage repair. Mutations in BRCA1 and BRCA2 genes have been linked to the development of hereditary breast cancer and ovarian cancer. BRCA gene mutation detection has also been highly recommended by many oncology clinical guidelines such as NCCN, CSCO and ASBrS guidelines, and the mutation testing results can guide use of PARP inhibitors such as Olaparib, surgical planning and screening for individual with high risk of ovarian cancer and/or breast cancer.BRCA1 and BRCA2 Gene Mutation Detection Kit (Reversible Terminator Sequencing) is intended for qualitative detection of BRCA1 and BRCA2 variants using DNA isolated from peripheral whole blood, fresh-frozen tissue or formalin-fixed paraffin-embedded (FFPE) tissue samples. The kit provides full and uniform coverage of both BRCA1 and BRCA2 genes, covering all coding exons, exon/intron junctions, some introns and UTR regions. The kit allows the detection of single nucleotide variants (SNVs) and insertions and deletions (Indels) from tissue-derived DNA, and the detection of SNVs, Indels, and large rearrangements (LRs) from blood-derived DNA.
The kit is intended to be used by trained professionals in a laboratory environment.
