EML4-ALK FUSION GENE DETECTION KIT

EML4-ALK Fusion Gene Detection Kit The anaplastic lymphoma kinase (ALK) gene is frequently involved in rearrangements that lead to gene fusions in lung cancer. Fusion partner of echinoderm microtubu

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EML4-ALK Fusion Gene Detection Kit

The anaplastic lymphoma kinase (ALK) gene is frequently involved in rearrangements that lead to gene fusions in lung cancer. Fusion partner of echinoderm microtubule-associated protein-like 4 (EML4) is frequently found in non-small-cell lung cancer (NSCLC). The recombinant EML4-ALK activates the receptor tyrosine kinase’s downstream signaling pathway, which includes PI3K/AKT, leading to carcinogenesis. It has been reported that the presence of the EML4-ALK fusion is correlated with the efficacy of 4LK-targeted therapy. Based on analysis of tumor messenger RNA, EML4-ALK fusions can be detected by real-time PCR method.

Features

1. Selectable

Pre-loaded and bulk formats are available.

 

2. Universal

Compatible with tissue samples.

 

3. Precise

Top sensitivity of 25 copies/rxn.

 

4.Easy

Two steps procedure, results in 150 mins.

 

5. Reliable

External control included.

Intended Use

EML4-ALK Fusion Gene Detection Kit is a real-time PCR assay for qualitative detection of 21 EML4-ALK fusions in total RNA extracted from formalin-fixed paraffin-embedded (FFPE) tumor tissue in NSCLC patients.

The kit is for research use only and intended to be used by trained professionals in a laboratory environment.

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